In this dissertation I explore applications of antibodies and alpaca-derived antibody fragments, known as VHHs, to understand severe acute respiratory associated coronavi [...]

Ubiquitin is a small 8 kDa protein that is appended onto lysine residues of proteins as a post-translational modification, and functions in regulating diverse cellular pr [...]

Testosterone therapy is considered standard of care medical treatment for transgender and gender diverse individuals assigned female at birth. The impact of gender affirm [...]

This dissertation presents a structure-informed deep learning framework for predicting protein ubiquitination sites using AlphaFold2-derived 3D structural features and gr [...]

Legionella pneumophila is a pathogenic organism ubiquitous in aqueous environments and the causative agent of Legionnaire's disease, a severe infection affecting the lung [...]

The chapters of this dissertation focus on understanding the mechanisms by which different CSF3R mutations identified in CNL drive leukemic transformation, with the ultim [...]