Opioids such as morphine, oxycodone, and fentanyl effectively relieve acute and post-operative pain, but long-term use can lead to tolerance. Chronic opioid use leads to [...]

The United States continues to face a significant opioid epidemic, with adolescence representing a critical period of vulnerability. Opioid prescriptions during adolescen [...]

Opioids are highly effective analgesics but frequently lead to tolerance and dependence. Opioid effects are mediated by the μ‑opioid receptor (MOR), whose regulation thro [...]

Rural communities are disproportionately impacted by the nation's current opioid epidemic. While access to buprenorphine, the gold standard of pharmaceutical treatment fo [...]

Opioids such as morphine are still the most effective analgesics for many types of pain. However, clinical utility of opioids is limited because long-term use leads to an [...]

Chronic non‑malignant pain is a prevalent public health issue associated with reduced quality of life, disability, and increased health care utilization. Chronic opioid t [...]

While historically, opioids have been used broadly to manage severe acute postoperative pain, recent studies have shown that patients are frequently prescribed opioids ei [...]

This dissertation investigates the dynamics of intracellular signaling cascades as a functional readout of neuromodulation. Specifically, newly developed fluorescence lif [...]