Sex differences in disease susceptibility, including infection, cancer, and autoimmunity, have been well-characterized, with males generally being more susceptible to inf [...]

Multiple Sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS) in which the degeneration of axons causes cumulative disability. The relat [...]

Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β cells and culminating with absolute insulin deficiency. Intensive insulin [...]

This dissertation showcases three independent studies that address various unknown aspects of a paraneoplastic syndrome called melanoma-associated retinopathy (MAR). Thro [...]

Autoimmunity to membrane proteins in the central nervous system has been increasingly recognized as a cause of neuropsychiatric disease. A key recent development was the [...]

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by immune-mediated destruction of myelin in the central nervous system, resulting in disrupted nerve [...]

Liver disease and type 1 diabetes affect millions, yet whole-organ transplantation remains the only definitive treatment, limited by donor scarcity and complications. Thi [...]

CD4 T cell effector functions are critical for protective immunity but can also drive pathological inflammation. The costimulatory receptor OX40 (CD134) enhances CD4 T ce [...]

This retrospective chart review investigates the relationship between mean platelet volume (MPV), a component of the widely accessible complete blood count (CBC), and imm [...]

Serious infections are a known concern for rheumatoid arthritis (RA) patients treated with anti‑TNF drugs, which suppress immune function. This study examined whether ant [...]