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Ubiquitin is a small 8 kDa protein that is appended onto lysine residues of proteins as a post-translational modification, and functions in regulating diverse cellular pr [...]
2020 |
Abstract |
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The goal of my PhD has been to develop and adapt optical chemical biology approaches to study signal transduction in cells. I developed genetically encoded FRET sensors t [...]
2024-10-31 |
Dissertation |
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T-cell large granular lymphocytic leukemia (T-LGLL) is a rare chronic lymphoproliferative disorder of mature cytotoxic T-cells. Accurate diagnosis relies on the integrati [...]
2020 |
Abstract |
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Fluorescent protein biosensors have become an important tool for neuroscience research. Highly optimized biosensors for Ca2+ are widely used to study neuronal activity in [...]
2022 |
Dissertation |
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Successful cancer treatment continues to elude modern medicine and its arsenal of therapeutic strategies. Therapy resistance is driven by tumor heterogeneity, complex int [...]
2020 |
Abstract |
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G protein-coupled receptors (GPCRs) play an essential role in signal transduction by transmitting extracellular stimuli into intracellular responses through activation of [...]
2023-09-22 |
Dissertation |
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