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Hemostasis is the process of sealing a vascular leak through concomitant activation of the blood coagulation cascade and blood platelet adhesion to and activation by the [...]

Formation of a hemostatic clot is essential for minimizing blood loss upon injury and is mediated, in part, by tightly regulated activity of and crosstalk between platele [...]

Platelets are the first defenders of vascular integrity, responding to vascular injury in a regulated sequence of adhesion, activation, and aggregation that enables form [...]

Pathological thrombosis is a significant driver of human morbidity and mortality today. Overall, this dissertation presents a study of the pathophysiology, clinical manag [...]