Kaposi’s sarcoma–associated herpesvirus (KSHV) uses immune‑evasion strategies to support successful infection, including the activity of its viral E3 ubiquitin ligase, K5 [...]

Viruses have co‑evolved with host immune systems, developing sophisticated strategies to evade antiviral defenses. Cytomegaloviruses (CMVs) are highly species‑specific ex [...]

Neisseria gonorrhoeae is the causative agent of gonorrhea, a common sexually transmitted infection. In this study, I characterize the fit locus and its role in host–patho [...]

Murine cytomegalovirus (MCMV) is a widely used model for studying β‑herpesvirus infection, eliciting strong CD8 T‑cell responses despite encoding multiple genes that bloc [...]

Murine cytomegalovirus (MCMV) encodes three immune evasion genes (m04, m06, and m152) that interfere with MHC class I antigen presentation to CD8 T cells. Although not re [...]

The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is characterized by restrained function of effector T cells and provides resistance to immunot [...]

Two closely related gammaherpesviruses, Kaposi’s sarcoma-associated herpesvirus (KSHV) and rhesus macaque rhadinovirus (RRV), are unique in that they express [...]

Cowpox virus (CPXV) is a member of the genus Orthopoxviridae (OPXV), which have been evolving alongside the mammalian immune system for millennia. CPXV possesses the la [...]

Varicella Zoster Virus (VZV) causes chickenpox upon primary infection and establishes latency in ganglia. Reactivation from latency causes herpes zoster, which may be c [...]

The major paradox confronting tumor immunology today is how tumor cells escape cell mediated immune destruction in hosts with demonstrable tumor immunity. Unfortunately, [...]