Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a marked propensity for liver metastasis and a poor overall prognosis. Although canonical d [...]

Pancreatic ductal adenocarcinoma (PDAC) has the lowest 5-year survival rate of all major malignancies (11%). In particular, late-stage malignancies have only a 5% 5-year [...]

Pancreatic Ductal Adenocarcinoma (PDAc) ranks among the top three most aggressive cancers in the United States and is projected to increase in incidence over the next few [...]

This cancer cell-intrinsic GOT2-PPARδ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive [...]

Chronic stress–driven sympathetic signaling influences cancer development by reshaping the tumor microenvironment (TME). This dissertation reviews how sympathetic nerves [...]

Cachexia is a devastating metabolic syndrome affecting up to 80% of patients with pancreatic ductal adenocarcinoma. Cardiac wasting and injury are common manifestations, [...]

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor outcomes, partly due to dysfunctional vascularization and complex tumor-stromal interactions. Th [...]

In order to improve treatment for a variety of forms of cancer, improved basic understanding of tumor microenvironments is needed. In this thesis, I review the state of t [...]

This study examined racial and regional differences in lymph node assessment and overall survival among 3,106 patients who underwent surgical resection for pancreatic ade [...]

A dissertation discussing the role of mesenchymal kit ligand (kitl) in the pancreas, specifically in regards to healthy tissue homeostasis, tissue architecture, and disea [...]