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Pancreatic ductal adenocarcinoma (PDAC) has the lowest 5-year survival rate of all major malignancies (11%). In particular, late-stage malignancies have only a 5% 5-year [...]

Pancreatic Ductal Adenocarcinoma (PDAc) ranks among the top three most aggressive cancers in the United States and is projected to increase in incidence over the next few [...]

This cancer cell-intrinsic GOT2-PPARδ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive [...]

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor outcomes, partly due to dysfunctional vascularization and complex tumor-stromal interactions. Th [...]

In order to improve treatment for a variety of forms of cancer, improved basic understanding of tumor microenvironments is needed. In this thesis, I review the state of t [...]

A dissertation discussing the role of mesenchymal kit ligand (kitl) in the pancreas, specifically in regards to healthy tissue homeostasis, tissue architecture, and disea [...]

Cachexia is a devastating syndrome with cardinal features of anorexia, weight loss, and fatigue. This syndrome occurs during numerous chronic diseases, such as cancer, ci [...]

Cancer cachexia is a co-morbidity highly prevalent in pancreatic ductal adenocarcinoma (PDAC) patients and results in a decreased quality of life.This work expands on pri [...]

Miles J. Edwards was a physician and professor. He completed his medical degree at the University of Oregon Medical School (UOMS, now Oregon Health & Science Universi [...]