Tumors overexpressing the HER2 oncogene account for around 20% of breast cancer cases and are associated with aggressive disease. These tumors generally originate from a [...]

Triple Negative Breast Cancer (TNBC) is a complex malignancy subtype which commonly forms aggressive tumors with substantial stromal involvement. Unlike the Luminal and H [...]

Patient stratification is essential for addressing breast cancer's inter- and intra-heterogeneity. While the PAM50 classifier is widely regarded to be the gold standard f [...]

This dissertation quantitatively assesses the single-cell spatial landscape of the tumor microenvironment for three cancer types. Statistical and machine learning approac [...]

Super resolution microscopy (SRM) comprises various single-molecule localization techniques that can generate images at the 20 nm scale. In recent years, SRM based on DNA [...]

The HER2+ subtype of breast cancer typically results from amplification of the proto-oncogene ERBB2, that causes overexpression of the mitogenic cell surface receptor kin [...]