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Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, d [...]
2023-08-18 | Abstract |
2.
The ability of tumors to induce immunosuppression and inhibit the cytolytic function of tumor-infiltrating lymphocytes (TIL) is a major obstacle to creating effective imm [...]
2020 | Dissertation |
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Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, d [...]
2024 | Abstract |
5.
Monoclonal antibodies targeting key receptors that inhibit T cell function such as CTLA-4 and PD-1 have demonstrated the potency of checkpoint blockade, highlighted by lo [...]
2021 | Thesis |
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The inability to develop an effective anti-tumor immune response plays a key role in cancer progression. Patients with a strong anti-tumor T cell response, indicated by i [...]
2016-09-01 | Thesis |
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The majority of research on T cells forms a paradigm in which classical T cells are activated by peptide antigens presented by classical MHC molecules. Non-classical T ce [...]
2016-09-01 | Dissertation |
8.
Vaccination of rhesus macaques with rhesus cytomegalovirus strain 68-1 expressing SIV proteins (RhCMV/SIV) results in stringent control of SIV replication. Approximately [...]
2016-06-01 | Dissertation |
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