Pathological thrombosis is a significant driver of human morbidity and mortality today. Overall, this dissertation presents a study of the pathophysiology, clinical manag [...]

The clinical standard for small diameter vessel treatment, currently, is the use of autologous vessels. However, due to limited availability and pre-surgical complication [...]

This dissertation focuses on studying familial platelet disorder and underlying mechanisms through which RUNX1 mutations impact the function of stem cells

Projection graphic of one in a series called "Pathologic changes in coronary-artery disease" showing an illustration of the brain and listing symptoms of coronary-artery [...]

The blood microenvironment is a dynamic system consisting of a diverse range of cells and plasma proteins that function together to maintain homeostasis. In my dissertati [...]

Atherosclerosis is the leading cause of cardiovascular disease, accounting for nearly 30% of deaths in the United States. Patients with late-stage atherosclerosis suffer [...]

The prevention of bleeding and protection of the vascular wall integrity is mediated by the blood cells platelets and enzymatic coagulation reactions in a process called [...]

Hemostasis is the process of sealing a vascular leak through concomitant activation of the blood coagulation cascade and blood platelet adhesion to and activation by the [...]

Formation of a hemostatic clot is essential for minimizing blood loss upon injury and is mediated, in part, by tightly regulated activity of and crosstalk between platele [...]