Atherosclerosis is the leading cause of cardiovascular disease, accounting for nearly 30% of deaths in the United States. Patients with late-stage atherosclerosis suffer [...]

Protein tyrosine kinases play an essential role within cells, transmitting signals to propagate a variety of fundamental cell functions. The activity of tyrosine kinases [...]

Genetic aberrations that cause constitutive activation of the receptor tyrosine kinase (RTK), ROS1, can drive cancer formation. Treatment of these cancers with tyrosine k [...]

How injury or neurodegenerative disease alter neural circuit function remains unclear. In this thesis, I explored how axotomy affects severed axons and adjacent uninjured [...]

Certain cancers, including gastrointestinal stromal tumor (GIST) and subsets of melanoma, are caused by somatic KIT mutations that result in constitutive KIT receptor tyr [...]