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Identification of druggable mutations in Acute Myeloid Leukemia (AML), such as FLT3-ITD, has led to the development of targeted therapies capable of out-performing cytoto [...]

This thesis describes fibroblast growth factor signaling in the development of resistance to tyrosine kinase inhibitor therapy in solid and hematologic malignancies, and [...]

Protein tyrosine kinases play an essential role within cells, transmitting signals to propagate a variety of fundamental cell functions. The activity of tyrosine kinases [...]