The Saccharomyces cerevisiae CPAI mRNA 5'-leader contains an evolutionarily conserved 25-codon upstream open reading frame (uORF), which genetic studies had suggested to [...]

With the advent of next-generation sequencing techniques like RNA-Seq, there is the potential for unbiased transcriptome-wide analysis of gene expression and alternative [...]

The use of synthetic mRNA-based gene modification offers several advantages over traditional DNA based gene therapy including faster translational kinetics, transient exp [...]

Cancers are among the most deadly and intractable of human diseases, for which the standard of care may involve aggressive yet only partially effective therapies. Immunot [...]

Rett syndrome is a neurological disease due to loss-of-function mutations in the transcription factor, Methyl CpG binding protein 2 (MECP2). Because overexpression of end [...]