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Pancreatic ductal adenocarcinoma (PDAC) has the lowest 5-year survival rate of all major malignancies (11%). In particular, late-stage malignancies have only a 5% 5-year [...]

Carcinoid tumors are neuroendocrine tumors which release prostaglandins and biogenic amines that can impact the cardiovascular system.1 In consequence, patients with meta [...]

This cancer cell-intrinsic GOT2-PPARδ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment, and fosters the immune-suppressive [...]

Interferon (IFN) family cytokines stimulate a broad group of genes known as interferon stimulated gene (ISGs). The primary function of ISGs is to provide antiviral host d [...]

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor in adults. Owing to a high level of disease heterogeneity and common recurrence, 5-year surviv [...]

In this case study, I demonstrate that CHCs are present in the blood of one patient with choroidal melanoma, lung adenocarcinoma, and a neuroendocrine tumor of the lung. [...]

There is a growing national demand to demonstrate quality of care, efficacious clinical outcomes and evidence based practice. Enhanced by Center for Medicare/Medicaid S [...]

Liquid biopsy provides a minimally-invasive alternative to solid tissue biopsy for assessing tumor-derived molecules such as circulating tumor DNA (ctDNA). Detection and [...]

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are the most common form of neuroendocrine neoplasia, but there is no current consensus for the sequencing of appr [...]

HER2-positive breast cancer is an aggressive subtype of breast cancer with patients having significantly lower survival rates compared to other breast cancers. HER2-posit [...]