The role, function, and generation of Eomeshi CD8+ T Cells in OX40 and CTLA-4 targeted cancer immunotherapy Public Deposited

Monoclonal antibodies targeting key receptors that inhibit T cell function such as CTLA-4 and PD-1 have demonstrated the potency of checkpoint blockade, highlighted by long-term complete responses for metastatic cancers once thought incurable. However, only a subset of patients will respond to checkpoint blockade due to a multitude of factors including an immunosuppressive tumor microenvironment and the mutational burden of the cancer.


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  • https://doi.org/10.6083/37720d444
  • Emerson.Dana.2021.pdf
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  • 2021
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