Advancements in the micro sensor and integrated chip technologies have led to the integration of sensors and the quantifying electronics in a single package. Various lab-on-chips (LOC) techniques have been developed and are usually geared towards the bio-tech industry, dealing frequently with analysis of target molecules in liquid medium. Similar integrated technology has also evolved for the detection of gaseous analytes and is commonly known as electronic nose or e-nose. It would be of great advantage if multiple targets in both liquid and gaseous mediums could be identified and quantified by a single device. This would also serve as a common platform for the development of new detection strategies. In this dissertation, I have developed a sensor-array chip hybrid for rapid parallel detection of multiple organic or inorganic target molecules in either gas or liquid mediums.