There has been a controversy among both clinicians and physiologists for a long time concerning the effects of various toxins on the thyroid gland. On one side, we have the evidence from exhaustive work done by McCarrison, in 1911, to show the feeding of fecal extracts and fecal residues to rats produced thyroid changes, loosely classed as “goitre”, in 100% of the animals. So closely to the symptoms of acute tuberculosis and acute toxic goitre resemble each other in the first stages that it has been definitively established by Goetsch, in the 1919, and Otis, in 1920, that the thyroid hypersecretion is involved in both.