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Abstract

Influenza is a disease that is estimated by the World Health Organization (WHO) to affect 5-10% of adults and 20-30% of children each year. Using this collaborative cross and available human data, this project sought to answer the following question: what genes and pathways are differentially expressed during mild and severe influenza infections in the collaborative cross mouse model, and do these mirror the differential expression seen in existing human influenza severity data?

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