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Studying LCHADD chorioretinopathy using a novel LCHADD mouse model
Babcock, Shannon
2024
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Abstract

The goal of this dissertation is to improve understanding and treatment for the chorioretinopathy seen in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) patients by examining the molecular mechanisms and testing potential treatments for LCHADD chorioretinopathy using a novel LCHADD mouse model.

Details

Title
Studying LCHADD chorioretinopathy using a novel LCHADD mouse model
Creator
Babcock, Shannon : Oregon Health and Science University : (0000-0003-2365-2119)
Contributor
Gillingham, Melanie PI (Oregon Health and Science University)
Publisher
Oregon Health and Science University
Date
2024-06-13
Subjects
Keywords
DOI
https://doi.org/10.6083/bpxhc43378
Language
English
Related Resource
Is part of: https://doi.org/10.1016/j.ymgme.2024.108351
Is part of: https://doi.org/10.1038/s42003-023-05268-1
Related work citations

1. Babcock, S. J., et al. (2024). "A review of fatty acid oxidation disorder mouse models." Mol Genet Metab 142(1): 108351.

2. Gaston G, Babcock S, Ryals R, Elizondo G, DeVine T, Wafai D, Packwood W, Holden S, Raber J, Lindner JR, Pennesi ME, Harding CO, Gillingham MB. A G1528C Hadha knock-in mouse model recapitulates aspects of human clinical phenotypes for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. Commun Biol. 2023 Aug 29;6(1):890. doi: 10.1038/s42003-023-05268-1. PMID: 37644104; PMCID: PMC10465608.

Content Type
Dissertation
Degree Type
Ph.D.
Academic Program
Molecular & Medical Genetics (sunsetting)
Department
Department of Molecular and Medical Genetics
School
School of Medicine
Grant Information
National Eye Institute
Copyright Status
Usage Statement
Record ID
43378
Record Created
2024-06-13
Record Appears in
OHSU Works > Student Work > Academic Programs > School of Medicine Programs > Molecular & Medical Genetics (sunsetted)
Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Molecular and Medical Genetics
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
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