Maintaining healthy levels of physical activity (PA) is a noninvasive, clinically proven means of reducing the onset of >40 chronic diseases and may provide a strategy for managing harmful alcohol use. Studies indicate a positive relationship between PA levels and alcohol intake in moderate drinkers, while heavy drinkers tend toward less physical activity. This suggests healthy PA levels may promote moderate alcohol intake and therefore harm reduction. Wheel-running (WR) – a well-characterized rodent model of voluntary PA – is known to reduce self-administration and craving for many drugs of abuse; however, its effects on alcohol intake are mixed.