Identifying genetic targets of Tau toxicity in Frontotemporal Dementia Drosophila model
Lowenstein, Eve
2025

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Abstract

Current treatments for FTD mitigate some behavioral changes, but there are no therapies that prevent or slow the progression of the disease. Profiling the epigenetic changes in FTD disease-associated Tau expressing Drosophila will help to elucidate the nuclear mechanisms of mutant Tau and yield insight into FTD disease progression.

Details

Title
Identifying genetic targets of Tau toxicity in Frontotemporal Dementia Drosophila model
Creator
Lowenstein, Eve : Oregon Health and Science University
Contributor
Kretzschmar, Doris Co-Mentor (Oregon Health and Science University)
Adey, Andrew Co-Mentor (Oregon Health and Science University)
Carbone, Lucia Committee chair (Oregon Health and Science University)
Unni, Vivek Committee member (Oregon Health and Science University)
Maslen, Cheryl Committee member (Oregon Health and Science University)
Martin, Ian Committee member (Oregon Health and Science University)
Publisher
Oregon Health and Science University
Date
2025-01-15
Subjects
Keywords
DOI
https://doi.org/10.6083/bpxhc44272
Language
English
Content Type
Dissertation
Degree Type
Ph.D.
Academic Program
Molecular & Medical Genetics (sunsetting)
Department
Department of Molecular and Medical Genetics
School
School of Medicine
Grant Information
National Institute on Aging
Copyright Status
Usage Statement
Record ID
44272
Record Created
2025-01-15
Record Appears in
OHSU Works > Student Work > Academic Programs > School of Medicine Programs > Molecular & Medical Genetics (sunsetted)
Organizations > Departments and Divisions > School of Medicine Basic Sciences Departments > Department of Molecular and Medical Genetics
OHSU Works > Student Work > Degrees > Doctor of Philosophy (Ph.D.)
Organizations > Schools > School of Medicine
OHSU Works > Student Work > Dissertations
Theses and Dissertations
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