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Abstract
This dissertation provides a deep exploration of how mammary epithelial cells respond to microenvironmental signals. Through a progression of increasingly complex models and integrative experimental approaches, we identified key regulatory networks and molecular mechanisms that link extracellular cues to cellular behavior. From cataloging transcriptional, proteomic, and phenotypic responses to uncovering the role of HIF1A in OSM-induced CCM and elucidating the synergistic effects of ligand combinations, this work advances our understanding of cellular signal integration.