The esthetic result of orthodontic therapy can be compromised by white spot lesion (WSL) development. WSLs are associated with increased bacterial accumulation exacerbated by orthodontic appliances and poor patient oral hygiene. One strategy to reduce WSL formation is to utilize orthodontic cements capable of releasing ions to inhibit bacterial growth and remineralize enamel. The Premier Dental Supply Company?s experimental cements incorporated with microcapsules containing a combination of Zn2+, PO43-, Ca2+, and F- were evaluated for their capability to minimize bacterial growth and the formation of WSLs and for their bond strength to enamel compared to a control. The experimental cements containing microencapsulated ions released significant levels of Zn2+, PO43-, Ca2+, and F- in an acidic aqueous solution (pH 5.15) over a 28-day period. The fluoride-containing formulation demonstrated a mild inhibition of bacterial growth. There were no significant differences in WSL formation on enamel for any of the cements. While there were no significant differences in the debonded adhesive remnants, the shear bond strengths were significantly lower for cements containing microcapsules, though they were still within the clinically-acceptable range. Future studies should focus on clinical capabilities of the cements and verify the adequacy of the bond strength.