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Abstract
Age, period, and cohort (APC) analysis helps uncover temporal influences on disease trends beyond simple rates. This study applied the multiphase APC method to Oregon viral hepatitis mortality data (1995–2010) to assess cohort effects among individuals born 1950–1965. Deaths were identified using ICD-9/10 codes and analyzed through graphical inspection, median polish, and regression modeling. Results showed significantly higher mortality for the 1950–1965 cohort compared to earlier (p=0.03) and later cohorts (p=0.003), with no significant period effects. Findings highlight a clear generational pattern, informing surveillance and public health planning for viral hepatitis.