Alzheimer's disease (AD) is an irreversible neurodegenerative disorder. It is the sixth leading cause of death in the United States. Genome-wide association studies have uncovered nearly 40 common genetic variants (minor allele frequency (MAF) > 5%) which are associated with increased susceptibility to AD. However, the common variants found so far do not completely account for the genetic component of the disease. With the technological advancement of deep sequencing, the focus has shifted to exploring the role of rare (MAF < 0.5%) and private variants.