Preliminary investigation and protocol development for in vitro optically stimulated luminescent dosimetry of multiple intrabeam applicators in a canine tissue model

The IntraBeam (Zeiss) intraoperative radiotherapy (IORT) device has been in wide use in the treatment of human cancers in the brain, breast, and other sites for more than a decade, but its use in Veterinary Medicine has thus far been exclusive to Oregon State University (OSU). OHSU and OSU have set about to do a dosimetric assessment on the IntraBeam as it relates to animal tissues. The purpose of this study was to make preliminary measurements in the Zeiss Water Phantom and in tissue to derive a protocol that would facilitate repeatable tissue measurements across multiple tissue types in the future.