The newly funded Building Research in Implementation and Dissemination to close Gaps and achieve Equity in Cancer Control (BRIDGE-C2) Center is one of three National Cancer Institute's Advanced Implementation Science Centers in Cancer Control. This innovative Center, based in the Department of Family Medicine at the Oregon Health & Science University and partnered with OCHIN, Inc., will provide a regional resource for dissemination and implementation (D&I) science. The BRIDGE-C2 Center's overarching goal is to advance D&I science to improve cancer screening and prevention in underserved populations. Community health centers (CHCs) provide excellent care to over 28 million people, but like many primary care practices serving populations impacted by health disparities, they face obstacles to delivering evidence-based cancer prevention to their patient populations. The BRIDGE-C2 Center will create tailored, focused approaches to support diverse practices' implementation of evidence-based interventions to close gaps in cancer prevention care.