Today’s genomics data requires a great deal of preprocessing before it can be utilized in analysis of biological questions. This work details the steps and requirements for processing genome‐wide association studies (GWAS) in preparation for analysis. The scripting language ‘Python’ is employed to open and read files of genomic datasets including phenotypic data, genotypic data, and demographics data, of a GWAS performed by the Harvard Brain Tissue Resource Center (HBTRC) as well as the Alzheimer’s Disease Neuroimaging Initiative (ADNI)