An increasing amount of attention is being given to the structural and morphological aspects of biological function, and by extension the computational challenges necessary to understand them are becoming increasingly important. In cancer re-search, structural changes in the tumor microenvironment and state changes in the cells, as well as the spatial distributions of proteins at both the tissue and cellular levels are key to understanding cancer progression and evolution. Imaging modalities are integral to the development of morpho-spatial analysis because they allow us to capture the structural information in tangent to the expression information across many different biological scales with high resolution.