Ionizing radiation (IR) is frequently used in the treatment of cancer through radiation therapy. However, exposure to IR also poses a significant safety risk for nuclear workers. The impact of IR on human cells, both normal and cancerous, is biologically important. This study has three main objectives: 1) to identify which genes are differentially expressed in cells exposed to radiation, 2) to uncover critical pathways influenced by these genes, and 3) to determine which drugs effectively target the differentially expressed pathways.