Approximately 20% of adults worldwide experience lower urinary tract symptoms (LUTS). The prevalence of LUTS increases with age, and in the US, over a quarter of adults older than 50 years of age are affected. Increasingly severe LUTS are associated with decreased physical and mental quality of life, stigma and psychological distress, and falls among older adults. This dissertation presents some of the first studies to investigate CS as a possible mechanism of LUTS in men.