Conventional dendritic cell (cDC) cross-presentation of tumor antigen within the lymph nodes is critical for antitumor immunity via the priming of tumor-specific CD8+ T c [...]

This work is an investigation into known and novel genetic contributions to male-factor infertility. We developed a computational pipeline for aggregating genotype-phenot [...]

Squamous cell carcinomas (SCCs) of the skin and head and neck frequently recur after therapy, a process driven in part by TGF-β-responding CSCs that exhibit invasive, poo [...]

The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is characterized by restrained function of effector T cells and provides resistance to immunot [...]

This is a retrospective case series that describes the clinical characteristics, treatment variation and outcomes of pediatric oncocytic thyroid carcinoma. It consists of [...]

Powassan virus is a lethal tick-borne flavivirus currently emerging in North America for which there are no therapies or vaccines. This dissertation focuses on developing [...]

This dissertation aims to address how ischemic injury induces cerebrovascular dysfunction and triggers a pathological cycle to accelerate the onset and progression of Alz [...]

This dissertation is focused on the role of post-endocytic sorting in opioid receptor regulation. Specifically, it describes the development of a chemical biology sensor [...]For the BioRxiv citation below, the paper is currently in press and should be released sometime in March (perhaps even by March 20th). If the in press citation is appropr [...]

This dissertation investigates the neural and metabolic mechanisms of asthma in offspring born to obese mothers.

Cachexia is a devastating metabolic syndrome affecting up to 80% of patients with pancreatic ductal adenocarcinoma. Cardiac wasting and injury are common manifestations, [...]