Powassan virus is a lethal tick-borne flavivirus currently emerging in North America for which there are no therapies or vaccines. This dissertation focuses on developing [...]

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of infectious disease mortality worldwide. Effective host immunity is critical by sampli [...]

Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset important in the early response to bacterial and viral lung pathogens. Upon activation, MAIT [...]

This dissertation characterizes cross-reactive immunity to emerging alpahviruses such as chikungunya virus in the context of infection or vaccination, in various models.

This work explores immunity induced by the yellow fever vaccine, 17D, efficacy. First, we provide a comprehensive review of breakthrough yellow fever infection. Next, we [...]

In this dissertation I explore applications of antibodies and alpaca-derived antibody fragments, known as VHHs, to understand severe acute respiratory associated coronavi [...]

Legionella pneumophila is a pathogenic organism ubiquitous in aqueous environments and the causative agent of Legionnaire's disease, a severe infection affecting the lung [...]

Interferon regulatory factor 6 plays a significant role in the regulation of intestinal epithelial cell identity, interferon response, and apoptosis.

Tuberculosis (TB) is a devastating illness. In the search for novel anti-TB therapies, there is growing interest in host-directed therapy (HDT), which seeks to synergize [...]

Dendritic cells (DCs) play a crucial role in mediating immune responses to pathogens and tumors, with their development influenced by signaling from the FLT3 receptor tyr [...]