Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a marked propensity for liver metastasis and a poor overall prognosis. Although canonical d [...]

Metastatic spread of disease accounts for the overwhelming majority of cancer-­related deaths, as current therapies are largely ineffective in treatin [...]

This dissertation investigates the unknown epigenetic basis of malignant cell states in pancreatic ductal adenocarcinoma (PDAC). By profiling human PDAC tumors with singl [...]EMBARGO: I would like to please request that this dissertation be embargoed. We are submitting the work presented in Chapter 2 for publication in Nature Genetics; this jo [...]

Current treatments for FTD mitigate some behavioral changes, but there are no therapies that prevent or slow the progression of the disease. Profiling the epigenetic chan [...]

Cell-cell co-occurrence patterns are critical in shaping biological and clinical phenotypes, but existing tools for analyzing single-cell RNA sequencing (scRNA-seq) data [...]

The prognosis for patients with the genetic neurological disorder Huntington's disease (HD) is incredibly poor. HD onsets in midlife, causes a variety of severe and debil [...]

The newsletter from the Roy Swank Multiple Sclerosis Clinic delivers vital updates, featuring the latest research, nutritious recipes, clinic developments, and more. The [...]

Idiopathic Intracranial Hypertension (IIH) is a condition characterized by elevated intracranial pressure without an identifiable cause and can lead to papilledema, visua [...]