Asthma is a highly prevalent airway disease characterized by inflammation, structural remodeling of the airways and airway hyperreactivity. Despite recent advances, asthm [...]

Atopic dermatitis is a chronic relapsing inflammatory disease of the skin characterized by chronic itch. Eosinophils, and eosinophils products, are present in the skin i [...]

Eosinophils, immune cells traditionally associated with allergic inflammation, are increasingly recognized for their interactions with the nervous system. In this study, [...]

Sepsis is a life‑threatening inflammatory response to infection and remains a major clinical challenge. Although sepsis causes widespread immune dysfunction and eosinopen [...]

Ozone is an environmental component of air pollution. It is a reactive oxygen species that acutely damages airway epithelium, increasing inflammatory cytokines, and neu [...]

This thesis investigates Acute Myeloid Leukemia, focusing on the PEAR1 gene and receptor, analyzed using the IL-3 withdrawal assay and other techniques. All bench work [...]

2025-03-19 | Thesis |

This work identifies a novel inhibitory role for muscarinic receptors on human and guinea pig eosinophils and demonstrates their functional importance in vivo. Muscarinic [...]

Asthma is a chronic inflammatory disease characterized by airway hyperreactivity, partly driven by sensory neuron dysfunction. This dissertation introduces a novel whole- [...]

Parasympathetic nerves strongly regulate airway tone, and in allergic asthma, excess acetylcholine release contributes to airway hyperresponsiveness linked to nerve‑assoc [...]