Search 11,183 records for:

Dendritic cells (DC) are mediators between innate and adaptive immune responses to pathogens and tumors. DC development is determined by signaling through the receptor ty [...]

Immune checkpoint inhibitors have shown success in treating a subset of patients with certain late-stage cancers. However, these treatments fail in many other patients, d [...]

Cell-cell co-occurrence patterns are critical in shaping biological and clinical phenotypes, but existing tools for analyzing single-cell RNA sequencing (scRNA-seq) data [...]

Complex networks that connect hundreds or thousands of nodes together can function properly through the use of nodes interacting, affecting and regulating one another. Ge [...]

Despite their devastating impacts on millions of people, most rare and congenital disorders remain poorly understood, leaving the patients with these disorders with no FD [...]

With the advent of next-generation sequencing techniques like RNA-Seq, there is the potential for unbiased transcriptome-wide analysis of gene expression and alternative [...]

Triple Negative Breast Cancer (TNBC) is a complex malignancy subtype which commonly forms aggressive tumors with substantial stromal involvement. Unlike the Luminal and H [...]

Immune checkpoint inhibitor (ICI) therapies, such as anti-PD1 and anti-CTLA4, have proved to be clinically effective in numerous malignant diseases due to their ability t [...]

Abnormal splicing events can promote drug resistance in a variety of cancer types, however, the full extent of genome-wide splicing in therapy-resistant AML is not fully [...]