The medial olivocochlear (MOC) system aids in the prevention of age- and noise-induced hearing loss, and enhances the detection of salient sound in diverse sensory enviro [...]

The descending pain modulatory pathway exerts bidirectional control of ongoing nociceptive inputs traveling from the body to the brain. Despite a large body of work impli [...]

The structural and functional characterization of the human bile acid ion channel in the presence and absence of calcium are discussed.

Understanding the molecular and genetic identity of neuron types is prerequisite to tractable control and investigation of the behavioral relevance of discrete neuronal t [...]

This dissertation examines how TAAR1 functionality influences dorsal raphe serotonin neuron activity, glutamatergic inputs, and methamphetamine (MA) intake in mice with d [...]

The insular cortex mediates diverse functions, including taste, interoception, decision making, and emotion regulation. However, the cellular and microcircuit mechanisms [...]

The brain regulates nociceptive processing through descending projections from the brainstem to the spinal and trigeminal dorsal horns. This is accomplished through endog [...]

Strong initial sensitivity to aversive drug effects likely results in drug avoidance and reduces the probability of addiction. The activation of glutamatergic lateral hab [...]