Metformin impacts syncytiotrophoblast mitochondrial function in a sexually dimorphic manner
Hebert, Jessica; Myatt, Leslie
2020

Files

Abstract

Placental mitochondrial respiration is impacted by obesity, type 2 gestational diabetes (A2GDM), and fetal sex. The mechanism of metformin, a "GDM treatment," is unclear, but it may inhibit mitochondrial complex I, reducing "mitochondrial respiration and ATP production." As previous studies examined the effect of metformin on cytotrophoblast but not syncytiotrophoblast (STB) we studied the effect on mitochondrial respiration in both male and female STB.

Details

Title Metformin impacts syncytiotrophoblast mitochondrial function in a sexually dimorphic manner
Creator Hebert, Jessica : Oregon Health and Science University
Myatt, Leslie : Oregon Health and Science University
Meeting Name Research Week, Oregon Health and Science University, 2020
Publisher Oregon Health and Science University
Date 2020
Subjects
Keywords
DOI https://doi.org/10.6083/bg257f61t
Language English
Content Type Abstract
Department Department of Obstetrics and Gynecology
School School of Medicine
Copyright Status
In copyright - joint owners
Usage Statement
Record ID 8339
Record Created 2023-06-29
Record Appears in Organizations > Departments and Divisions > School of Medicine Clinical Sciences Departments and Divisions > Department of Obstetrics and Gynecology
Organizations > Schools > School of Medicine
OHSU Works > Events > Research Week
All Records

PDF

Statistics

from
to
Export
Download Full History