Bone defects can occur after trauma, infection, or oncologic resection and autologous bone grafting is the current treatment option. However, this method has its limitations in more severe injuries as it may cause infection and scarring at donor sites. Thus, developing biomaterials that are osteoinductive with live cells is essential for treating bone defects. We are creating a bone-like structure that are biomineralized to the nanoscale level and embedded with human mesenchymal stem cells (hMSCs) that undergo osteogenic differentiation without any conventional supplements.
Details
Title
Faster biomineralization and osteogenesis on-a-chip using 3D bioprinting and microfluidics
Creator
Visalakshan, Rahul M. : Oregon Health and Science University Sousa, Mauricio : Oregon Health and Science University Taheri, Anthony : Oregon Health and Science University Athirasala, Avathamsa : Oregon Health and Science University Bertassoni, Luiz : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2023