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Abstract

Structural biology is ultimately the study of particular domains and residues, but this knowledge most interesting and useful in the con-text of physiological processes. As such, it can be difficult to order the chapters of an introduction. Placing the structure before the function grounds discussion of mutations and disease, but leaves the structure unmoored from biomedical relevance. Conversely, placing function first leaves the reader without a clear understanding of which do-mains are important for which reasons, which is vital for a focused discussion of the protein. To dodge the question of which is the cart and which is the course, I present here an exceedingly brief (and less heavily cited) discussion of ENaC structure and function.

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