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Abstract

Globally, Taenia solium contributes to an estimated 2.8 million disability-adjusted life years per year, the most significant public health burden of any foodborne parasite. In communities where T. solium is endemic, the dual threat of taeniasis (the intestinal infection) and epilepsy caused by neurocysticercosis (NCC, the central nervous system [CNS] infection) causes extensive population morbidity and complicates community-based health care delivery. Despite its impact, as a neglected tropical disease, the available evidence on safe and appropriate healthcare practices for T. solium-related diseases also remains neglected. This dissertation research addresses these gaps by 1) describing the prevalence of viable NCC among individuals being considered for treatment of taeniasis, 2) assessing the relationship between NCC and time to seizure control among people with epilepsy initiating ASM treatment, and 3) examining the association between the epilepsy treatment gap and health related quality of life, stratified by NCC. All three aims represent populations living in Northern Peru – an area highly endemic with T. solium.

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