The flavivirus Zika virus (ZIKV) has extensive human health impact yet lacks vaccines and antiviral treatments in part due to gaps in understanding of the its infectious cycle. To gain further insight into the infectious cycle without complete ablation of host or viral proteins we designed alpaca derived variable-heavy-chain antibody fragments (VHHs) against ZIKV. VHHs are encoded on a single gene, can be expressed in mammalian cells, and bind cognates in cytoplasm.
Details
Title
Characterization of single-domain antibodies against Zika virus structural and non-structural proteins
Creator
Weinstein, Jules : Oregon Health and Science University Merutka, Ilaria : Oregon Health and Science University Tafesse, Fikadu : Oregon Health and Science University
Contributor
Cebra, Christopher Collaborator (Oregon State University) Hirsch, Alec Collaborator (Oregon Health and Science University)
Meeting Name
Research Week, Oregon Health and Science University, 2020