Alzheimer's disease (AD) is a neurological disorder that affects 44 million people worldwide and is the leading cause of dementia. It is characterized by memory loss, challenges with executive function, and difficulties learning and storing new information, among many other symptoms. Age is the most significant risk factor for AD, interacting with several genetic and environmental risk factors to contribute to disease manifestation. In addition to AD, age-related cognitive decline (ACD) and mild cognitive impairments (MCI) are of increasing concern with the increased longevity. There might be protective factors that can help mitigate the development of ACD, MCI, and AD. In this pilot study, we started to explore the effects of exercise as possible protective factor in human apoE mice. Voluntary wheel running, even in mild bouts, can improve cognition, memory, and executive function.