Sleep deprivation studies indicate an essential role for sleep in the pathophysiology of many conditions, with sleep at a lifetime maximum during early life. Previous research in our lab using an early life sleep disruption (ELSD) paradigm has shown long lasting deficits in complex social and cognitive behaviors in adult prairie voles. We hypothesized that increased time spent awake during ELSD may cause a transient increase in excitatory neurotransmission, leading to morphological changes in dendritic spines and long lasting changes in excitatory neurotransmission
Details
Title
Dendritic spine morphology and excitatory neurotransmission in prefrontal cortex is altered after early life sleep disruption
Creator
Olson, Randall : Oregon Health and Science University Jones, Carolyn E. : Oregon Health and Science University Chau, Alex Q. : Oregon Health and Science University Puranik, Niyati : Oregon Health and Science University Moore, Cynthia : Oregon Health and Science University Wickham, Peyton T. : Oregon Health and Science University Meshul, Charles K. : Oregon Health and Science University Lim, Miranda M. : Oregon Health and Science University
Meeting Name
Research Week, Oregon Health and Science University, 2020
