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Abstract

Administration of chemotherapy via intra-arterial (IA) route results in a higher concentration of targeted chemotherapy against resilient brain malignancies with a decreased systemic chemotherapy side effect. Osmotic blood-brain barrier disruption (BBBD) further intensify drug delivery and effects on brain malignancies. The aim of this study is to determine the safety of the use of intra-arterial chemotherapy and blood brain barrier disruption to treat malignant brain tumors.

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