Most patients with solid tumors do not respond to immune checkpoint blockade, often because their tumors lack sufficient cytotoxic CD8+ T cells. Interleukin-2 (IL-2) can [...]

My research focuses on cancer immunotherapy, biomaterials, and targeted drug delivery. During my M.S. in Biomedical Engineering, I investigated peptide amphiphile-based d [...]

We demonstrate that the proportions of different functional tissue units (FTUs) within prostate tissue constitute a simple, biologically interpretable, and effective whol [...]

This dissertation presents deep learning frameworks for automated retinal biomarker quantification and AMD severity staging using volumetric OCT and OCTA. The work includ [...]

This thesis investigates the development and application of spectrally distinct fluorescent probes for fluorescence-guided surgery (FGS) to improve intraoperative visuali [...]

This dissertation integrates control theory modeling and spatial phenotyping to address the dual challenges of treatment resistance and diagnostic precision in oncology. [...]

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a marked propensity for liver metastasis and a poor overall prognosis. Although canonical d [...]

This thesis defines a continuum linking molecular-level interactions to complex coagulation phenotypes observed in disease states.

This work focuses on developing visible-light optical coherence tomography systems for high-resolution, noninvasive imaging of the cornea and anterior segment of the eye. [...]

This dissertation demonstrates that engineered collagen-based microenvironments can be designed to improve craniofacial bone regeneration by integrating matrix mechanics, [...]