Acute myeloid leukemia (AML) is a malignancy with a poor survival rate, primarily due to resistance to chemotherapy.Combination therapy using gilteritinib with venetocla [...]

MYC is an enigmatic master regulator implicated in nearly every facet of cellular biology. Throughout my PhD research and deep engagement with the literature, my singular [...]

Androgen hormones regulate the activity of myriad cells of the immune system and are strong drivers of sex differences in disease susceptibility, yet little is known of t [...]

The majority of PDGFRA-mutant gastrointestinal stromal tumors (GIST) harbor exon 18 mutations, most commonly D842V, which is treated with avapritinib (a new type I TKI) b [...]

The work presented herein advances our understanding of neoplastic-immune hybrid cells as drivers of cancer progression and metastasis. My dissertation studies reveal sh [...]

This dissertation investigates the role of weaning-induced liver tissue remodeling, known as involution, on stromal cells in the liver. We transcriptionally investigate c [...]

Pioneer neurons establish the initial nervous system structure by extending axons toward distant targets, but their molecular distinction from follower neurons was previo [...]

This thesis investigates Acute Myeloid Leukemia, focusing on the PEAR1 gene and receptor, analyzed using the IL-3 withdrawal assay and other techniques. All bench work [...]

2025-03-19 | Thesis |

A dissertation discussing the role of mesenchymal kit ligand (kitl) in the pancreas, specifically in regards to healthy tissue homeostasis, tissue architecture, and disea [...]

Tight regulation of the proliferative status of intestinal stem cells is critical for establishing a functional epithelial layer during development, a homeostatic state i [...]