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1.
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Clonal hematopoiesis (CH) involves a single hematopoietic stem/progenitor cell (HSPC) gaining a selective advantage due to somatic mutations, increasing the risk of hemat [...]
2024-06-14 |
Thesis |
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2.
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This thesis describes the role of RI-I modulation in the vascular system. I identify a novel role for RIG-I activation in endothelial function, as well as a role for RIG- [...]
2024-02-07 |
Dissertation |
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3.
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Individuals who inherit a pathogenic mutation in SDHA have an increased risk of cancer. However, there is often insufficient evidence to properly assess pathogenicity, an [...]
2023-12-14 |
Dissertation |
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4.
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Central nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturat [...]
2023-09-01 |
Dissertation |
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5.
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Metastatic spread of cancer is responsible for the vast majority of cancer-related deaths highlighting the need to better understand the cellular mechanisms underlying th [...]
2023-08-21 |
Abstract |
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6.
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Pioneer neurons are the first to extend their axons into a target tissue during nervous system development. Pioneer axon tracts act as a scaffold for subsequent extension [...]
2023-08-18 |
Abstract |
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7.
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Immune checkpoint blockade (ICB) has revolutionized the ways in which we treat some cancers, producing durable responses. However, many patients fail to respond to ICB. I [...]
2023-08-16 |
Dissertation |
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8.
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We live in a world filled with nearly constant tactile stimuli, and our perceptions of and responses to these stimuli shape our many interactions. Processing the incredib [...]
2022 |
Dissertation |
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9.
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The greatest risk factor for developing Parkinson's disease is aging, and the accumulation of reactive oxygen species is thought to play a significant role in the aging p [...]
2022 |
Thesis |
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10.
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Genetic heterogeneity makes clinical interventions challenging for patients with acute myeloid leukemia (AML). Identifying and targeting common microenvironment-driven pa [...]
2022 |
Dissertation |
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