Department of Cell, Developmental and Cancer Biology

This dissertation investigates the role of weaning-induced liver tissue remodeling, known as involution, on stromal cells in the liver. We transcriptionally investigate c [...]

Pioneer neurons establish the initial nervous system structure by extending axons toward distant targets, but their molecular distinction from follower neurons was previo [...]

This thesis investigates Acute Myeloid Leukemia, focusing on the PEAR1 gene and receptor, analyzed using the IL-3 withdrawal assay and other techniques. All bench work [...]

2025-03-19 | Thesis |

A dissertation discussing the role of mesenchymal kit ligand (kitl) in the pancreas, specifically in regards to healthy tissue homeostasis, tissue architecture, and disea [...]

Tight regulation of the proliferative status of intestinal stem cells is critical for establishing a functional epithelial layer during development, a homeostatic state i [...]

The mutational status of platelet-receptor PEAR1 was recently identified as a major factor for survival of young patients with Acute Myeloid Leukemia. While studies show [...]

Clonal hematopoiesis (CH) involves a single hematopoietic stem/progenitor cell (HSPC) gaining a selective advantage due to somatic mutations, increasing the risk of hemat [...]

This thesis describes the role of RI-I modulation in the vascular system. I identify a novel role for RIG-I activation in endothelial function, as well as a role for RIG- [...]

Individuals who inherit a pathogenic mutation in SDHA have an increased risk of cancer. However, there is often insufficient evidence to properly assess pathogenicity, an [...]

Central nervous system demyelination occurs in numerous conditions, including multiple sclerosis (MS). Remyelination in acute lesions involves the recruitment and maturat [...]