Conventional dendritic cell (cDC) cross-presentation of tumor antigen within the lymph nodes is critical for antitumor immunity via the priming of tumor-specific CD8+ T c [...]

Metabolic reprogramming is a fundamental hallmark of cancer, enabling tumors to sustain rapid proliferation and evade treatment by dynamically shifting nutrient acquisiti [...]

Lack of histopathologic characterization of BCLM tumors further limits development of targeted therapeutics. Methods: We collected BCLM tissues from 47 OHSU breast cancer [...]

The chapters of this dissertation focus on understanding the mechanisms by which different CSF3R mutations identified in CNL drive leukemic transformation, with the ultim [...]

Squamous cell carcinomas (SCCs) of the skin and head and neck frequently recur after therapy, a process driven in part by TGF-β-responding CSCs that exhibit invasive, poo [...]

The overall aim of this work is to understand how biallelic CEBPA mutations block differentiation and contributed to the development of acute myeloid leukemia (AML). This [...]

Acute myeloid leukemia (AML) is a malignancy with a poor survival rate, primarily due to resistance to chemotherapy.Combination therapy using gilteritinib with venetocla [...]

MYC is an enigmatic master regulator implicated in nearly every facet of cellular biology. Throughout my PhD research and deep engagement with the literature, my singular [...]

Androgen hormones regulate the activity of myriad cells of the immune system and are strong drivers of sex differences in disease susceptibility, yet little is known of t [...]

The majority of PDGFRA-mutant gastrointestinal stromal tumors (GIST) harbor exon 18 mutations, most commonly D842V, which is treated with avapritinib (a new type I TKI) b [...]