Coronary artery disease, a leading cause of death in the United States, is commonly treated with arterial stents. Common issues with cobalt chromium (CoCr) and stainless- [...]

Work in this thesis characterizes the cellular phenotype of a novel progenitor-derived endothelial-like cell, two in vivo assessments of bioprosthetic venous valve endo [...]

Small-diameter vascular grafts remain a critical unmet need due to limitations of autologous vessels and synthetic grafts. This work investigates the role of extracellula [...]

Cardiovascular disease affects nearly half of all U.S. adults and is the leading cause of death worldwide. Advanced cases are often treated through vascular grafting to b [...]

This dissertation demonstrates that engineered collagen-based microenvironments can be designed to improve craniofacial bone regeneration by integrating matrix mechanics, [...]

Cardiovascular diseases (CVD) such as ischemic heart disease and peripheral artery disease, continue to be the leading cause of death worldwide. The primary underlying ca [...]

The clinical standard for small diameter vessel treatment, currently, is the use of autologous vessels. However, due to limited availability and pre-surgical complication [...]

Atherosclerosis is closely linked to endothelial cell (EC) function, which is strongly influenced by fluid shear stress (FSS). While high, unidirectional FSS produces elo [...]

Platelets are the first responders to vascular injury, playing a critical role in the formation of a hemostatic plug to stop and prevent blood loss. This process requires [...]

Articular cartilage is the tissue at the junction of bones where it's highly organized anisotropic structure facilitates its biomechanical function during skeletal motion [...]