Glial cells are critical for maintaining a healthy nervous system. Key regulatory functions include synaptic remodeling, metabolic support of neurons, and protective immu [...]

Neuropathy Target Esterase (NTE) is an enzyme localized to the ER that regulates Protein Kinase A (PKA) signaling and maintains lipid homeostasis. Exposure to a neurotox [...]

Glial cells are the primary immune responders in the central nervous system, rapidly clearing degenerating tissue after injury, yet the molecular mechanisms driving this [...]

Glial cells refine synaptic signaling, ensheath axonal projections and, importantly, are the first immune responders in the brain after trauma or stress. During reactiv [...]

This dissertation characterizes the developmental remodeling of a subset of neurons in the Drosophila nervous system. We highlight how these neurons undergo remodeling of [...]

The brain is a dense network of precisely interconnected cells called neurons. Our thoughts and behaviors require communication between billions of individual neurons tha [...]

Recent advances in glial cell research have proven that glial cells are much more than brain “glue,” and that glia perform numerous important functions in vertebrate and [...]

Glial cells perform paramount functions within the nervous system, closely monitoring and regulating neurons. Indispensable roles for glia have been elucidated in most as [...]